Electrochemical sensor for Serotonin based on a composite made of core-shell molecularly imprinted polymer nanoparticles and polyethilenedioxythiophene

Author

Introna, Barbara ; Malitesta, Cosimino ; Mazzotta, Elisabetta ; Rella, Simona ; Mohammadi, Reza ; Ramezany, Farid ; Sellergren, Borje

Author_Institution

Dipt. di Sci. e Tecnol. Biologiche ed Ambientali, Univ. del Salento, Lecce, Italy

fYear

2015

fDate

3-5 Feb. 2015

Firstpage

1

Lastpage

4

Abstract

The “grafting from” synthesis of core-shell molecularly imprinted polymer nanoparticles (Ser-MIP@SiO₂ NPs) has been applied to the development of an electrochemical sensor for Serotonin. Ser-MIP@SiO₂ NPs have been synthesized on preformed SiO₂ nanobeads by surface imprinting via reversible additionfragmentation chaintransfer (RAFT) polymerization. After polymerization, the reductive aminolysis of dithioesther end group has been carried out. Then MIP-nanoparticles were subsequently characterized by ATR-FTIR, TGA, TEM and XPS. The entrapment of core-shell Ser-MIP@SiO₂ NPs by the electropolymerization of PEDOT in an upside-down electrochemical cell has been investigated. Under selected conditions, results in sensing application for Serotonin are presented.

Keywords

Fourier transform infrared spectra; X-ray photoelectron spectra; attenuated total reflection; biochemistry; biosensors; core levels; core-shell nanostructures; electrochemical sensors; nanocomposites; nanofabrication; nanomedicine; nanoparticles; polymerisation; polymers; silicon compounds; transmission electron microscopy; ATR-FTIR; Fourier transform infrared spectra; MIP-nanoparticle; PEDOT electropolymerization; RAFT polymerization; Ser-MIP-SiO₂ nanoparticle synthesis; SiO₂; X-ray photoelectron spectra; attenuated total reflectance; core-shell Ser-MIP-SiO2 nanoparticle entrapment; core-shell molecularly imprinted polymer nanoparticle; dithioesther end group reductive aminolysis; electrochemical sensor development; polyethilenedioxythiophene; reversible addition fragmentation chaintransfer; serotonin; silicon dioxide nanobeads; surface imprinting; thermal gravimetric analysis; transmission electron microscopy; Chemicals; Electrodes; Films; Nanoparticles; Polymers; Silicon compounds; core-shell nanoparticles; electrochemical sensors; molecularly imprinted polymers; polyethylenedioxythiophene (PEDOT); serotonin;

fLanguage

English

Publisher

ieee

Conference_Titel

AISEM Annual Conference, 2015 XVIII

Conference_Location

Trento

Type

conf

DOI

10.1109/AISEM.2015.7066843

Filename

7066843