Title :
A cytoskeleton linearity measure
Author :
Sturm, Deborah ; Jawad, Mahdi ; Alonso, Alejandra ; Corbo, Chris
Author_Institution :
Dept. of Comput. Sci., Coll. of Staten Island (CUNY), Staten Island, NY, USA
Abstract :
We developed a measure of cytoskeletal linearity in order to study the biological properties of normal and hyperphosphorylated Microtubule Associated Protein Tau (MAPT). The effect of site-specific tau phosphorylation on the microtubule network was examined and the stability of the actin cytoskeletal was evaluated to determine its state under the influence of P-tau. A custom ImageJ plugin using the linear Hough transform was developed to quantify the linearity of polymerized actin.
Keywords :
Hough transforms; biology computing; biomedical engineering; cellular biophysics; diseases; nanobiotechnology; proteins; Alzheimer disease; ImageJ plugin; MAPT; P-tau; actin cytoskeletal; biological properties; cytoskeleton linearity measure; hyperphosphorylated microtubule associated protein; linear Hough transform; microtubule network; neurodegenerative process; normal microtubule associated protein; polymerized actin linearity; tau phosphorylation; Dementia; Humans; Linearity; Mice; Proteins; Transforms; Hough transform; actin cytoskeleton; feature extraction; linearity measure;
Conference_Titel :
Image Analysis and Interpretation (SSIAI), 2012 IEEE Southwest Symposium on
Conference_Location :
Santa Fe, NM
Print_ISBN :
978-1-4673-1831-0
Electronic_ISBN :
978-1-4673-1829-7
DOI :
10.1109/SSIAI.2012.6202449
