Title :
Mathematical modeling of dermal wound healing: A numerical solution
Author :
Azizi, Aydin ; Osgouie, Kambiz Ghaemi
Author_Institution :
Dept. of Mech. Eng., Sharif Univ. of Technol., Tehran, Iran
Abstract :
Though wound healing process is well-researched, this area is poorly known. One reason is that all interactions have not been discovered, the main reason, though, is that the involved processes interact in a very complicated manner with nonlinear feedback. Such complex feedback mechanisms can be easily addressed by mathematical modeling. This paper contains a review of the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing with focusing on remodeling phase. The models are of partial differential equation type and solved by numerical method.
Keywords :
cellular biophysics; feedback; partial differential equations; skin; wounds; cell interaction; complex feedback mechanisms; dermal wound healing; extracellular matrix components; mathematical modeling; nonlinear feedback; numerical method; partial differential equation; remodeling phase; Cells (biology); Dermis; Elasticity; Electrochemical machining; Extracellular; Feedback; Fibroblasts; Mathematical model; Protocols; Wounds; mathematical model; numerical method; remodeling phase; wound healing;
Conference_Titel :
Computer and Automation Engineering (ICCAE), 2010 The 2nd International Conference on
Conference_Location :
Singapore
Print_ISBN :
978-1-4244-5585-0
Electronic_ISBN :
978-1-4244-5586-7
DOI :
10.1109/ICCAE.2010.5451433