DocumentCode :
2160737
Title :
Real and complex genomic signals
Author :
Cristea, Paul
Author_Institution :
"Politehnica" Univ. of Bucharest, Romania
Volume :
2
fYear :
2002
fDate :
2002
Firstpage :
543
Abstract :
The paper discusses the ways of converting DNA sequences from their symbolic - nucleotide, codon and amino acid - forms into corresponding digital signals. It is shown that all the real and complex mappings can be derived from the same original tetrahedral representation of the genetic code (GC). The reduction of the representation dimensionality results from the projection of the GC tetrahedron on adequately oriented planes or surfaces. On these bases, optimal symbolic-to-digital mappings of the DNA strands into real or complex genomic signals are derived at nucleotide, codon and amino acid levels. By converting the nucleic acid and polypeptide sequences into digital genomic signals, this approach offers the possibility to use a large variety of signal processing methods for their handling and analysis. It is also shown that some essential features of the nucleotide sequences can be better extracted using this representation. Results obtained by applying this approach for the analysis of the human genome are presented along with some new methods for identifying genetically significant segments of DNA sequences.
Keywords :
DNA; medical signal processing; sequences; DNA sequences; GC tetrahedron; amino acid; codon; complex genomic signals; digital genomic signals; genetic code; genetically significant segments; human genome; nucleic acid; nucleotide; optimal symbolic-to-digital mappings; polypeptide sequences; real genomic signals; representation dimensionality reduction; signal processing; tetrahedral representation; Amino acids; Bioinformatics; DNA; Digital signal processing; Genetics; Genomics; Sequences; Signal analysis; Signal mapping; Signal processing;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Digital Signal Processing, 2002. DSP 2002. 2002 14th International Conference on
Print_ISBN :
0-7803-7503-3
Type :
conf
DOI :
10.1109/ICDSP.2002.1028147
Filename :
1028147
Link To Document :
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