Title :
Resonant cavity imaging biosensor
Author :
Bergstein, David A. ; Ruane, Michael F. ; Goldberg, Bennett B. ; Ünlü, M. Selim
Author_Institution :
Boston Univ., MA, USA
Abstract :
The resonant cavity imaging biosensor (RCIB) detects binding between target biomolecules in solution and probe biomolecules fixed to a microarray surface. IR light couples resonantly through a 1 cm square cavity constructed from Si/SiO2 Bragg mirrors that contains the microarray surface. As the wavelength of the probe beam is swept, an IR camera monitors cavity transmittance at each pixel. The current setup detects 5 nm relief structures etched in the SiO2 surface of one of the Bragg mirrors. RCIB improves on existing label-free biosensing techniques by offering the combination of high sensitivity, high throughput, and real-time observation.
Keywords :
biomedical measurement; biomedical optical imaging; cavity resonators; image sensors; infrared imaging; micromirrors; molecular biophysics; optical arrays; 5 nm; Bragg mirrors; IR camera; IR light resonant coupling; Si-SiO2; Si/SiO2 mirrors; binding detection; cavity transmittance; etched relief structures; high sensitivity observation; high throughput observation; imaging biosensor; microarray surface; probe beam; probe biomolecules; real-time observation; resonant cavity biosensor; solution biomolecules; target biomolecules; Biosensors; Cameras; Etching; Mirrors; Molecular biophysics; Optical coupling; Optical imaging; Probes; Resonance; Throughput;
Conference_Titel :
Lightwave Technologies in Instrumentation and Measurement Conference, 2004. Proceedings of the
Print_ISBN :
0-7803-8722-8
DOI :
10.1109/LTIMC.2004.1371002
