Effects of EMP on bone formation of MC3T3-E1 cells

Author

Li, Kangchu ; Ma, Shirong ; Ding, Guirong ; Zhou, Yongchun ; Wang, Xiaowu ; Zeng, Lihua ; Chen, Yongbin ; Su, Xiaoming ; Guo, Guozhen ; Guo, Yao

Author_Institution

Dept. of Radiat. Med., Fourth Mil. Med. Univ., Xi´´an

fYear

2008

fDate

2-5 Nov. 2008

Firstpage

895

Lastpage

897

Abstract

The purpose of this study was to investigate the effects of electromagnetic pulse (EMP) on bone formation of MC3T3-E1 cells. Proliferation, ALP activity and mineralized nodule formation were examined in MC3T3-E1 cells after EMP exposure (field intensities: 0 kV/m, 50 kV/m, 400 kV/m, 400 pulses once a day for 7 days). After 50 kV/m EMP exposure, all the parameters of MC3T3-E1 cells were not changed significantly. However, the proliferation, ALP activity and mineralized nodule formation of MC3T3-E1 cells in 400 kV/m EMP exposure groups were decreased. In conclusion, the EMP we used was a possibly harmful factor for bone formation. It may suppress bone formation of MC3T3-E1 cells with higher electric field intensity.

Keywords

biological effects of fields; bone; cellular effects of radiation; electromagnetic pulse; orthopaedics; ALP activity; EMP; MC3T3-E1 cells; bone formation; electric field intensity; electromagnetic pulse; mineralized nodule formation; proliferation; Bones; Cells (biology); Crystals; EMP radiation effects; Electromagnetic scattering; Filters; Mineralization; Pathology; Pulse generation; Temperature; ALP; EMP; MC3T3-E1; Mineralized nodule; Proliferation;

fLanguage

English

Publisher

ieee

Conference_Titel

Antennas, Propagation and EM Theory, 2008. ISAPE 2008. 8th International Symposium on

Conference_Location

Kunming

Print_ISBN

978-1-4244-2192-3

Electronic_ISBN

978-1-4244-2193-0

Type

conf

DOI

10.1109/ISAPE.2008.4735362

Filename

4735362