Title :
Time-correlated Two-photon Fluorescence Imaging with Arrays of Solid-state Single Photon Detectors
Author :
Gersbach, M. ; Boiko, D.L. ; Sergio, M. ; Niclass, C. ; Petersen, C. ; Charbon, E.
Author_Institution :
Ecole Polytech. Fed. de Lausanne, Lausanne
Abstract :
This paper reports on our progress in developing multibeam two-photon fluorescence lifetime imaging microscopy (FLIM) based on time-correlated single-photon counting (TCSPC). The core of the system is a 2D array of solid-state single-photon avalanche diodes (SPADs) operating simultaneously and at room temperature. To the best of our knowledge, this is the first solid-state demonstration of a two-photon multichannel FLIM system with a time resolution of 120ps.
Keywords :
avalanche diodes; fluorescence; sensors; two-photon processes; multibeam two-photon fluorescence lifetime imaging microscopy; solid-state single photon detectors; solid-state single-photon avalanche diodes; time 120 ps; time-correlated single-photon counting; time-correlated two-photon fluorescence imaging; two-photon multichannel FLIM system; Calcium; Detectors; Diodes; Fluorescence; Microchannel; Microscopy; Sensor arrays; Solid state circuits; Temperature; Time measurement;
Conference_Titel :
Lasers and Electro-Optics, 2007 and the International Quantum Electronics Conference. CLEOE-IQEC 2007. European Conference on
Conference_Location :
Munich
Print_ISBN :
978-1-4244-0931-0
Electronic_ISBN :
978-1-4244-0931-0
DOI :
10.1109/CLEOE-IQEC.2007.4386631
