Title :
Deep Capture of Paramagnetic Particle for Targeting Therapeutics
Author :
Gong, Yongyong ; Pei, Ning ; Huang, Zheyong ; Ge, Junbo ; Ma, Wenli ; Zheng, Wenling
Author_Institution :
Coll. of Sci., Shanghai Univ., Shanghai, China
Abstract :
Magnetic targeting, a promising therapeutic strategy for localizing systemically-delivered drug to target tissue, is limited by magnetic attenuation. A special apparatus was developed to fulfill deep magnetic targeting. Due to special shape of poles and magnetic shields, the magnetic field produced by this apparatus was stronger at the center of the air gap than any other place along two directions. The magnetic field could make deep capturing along these directions. To test the aggregation property of this apparatus, the accumulation of 500-nm paramagnetic particles was observed as flowing through a tube served as a model of blood vessels. The relationship of the accumulation of the paramagnetic particles and effectiveness of the magnetic shielding was studied.
Keywords :
biomagnetism; blood vessels; drugs; magnetic shielding; nanobiotechnology; nanoparticles; paramagnetic materials; physiological models; aggregation property; blood vessel model; magnetic shielding; magnetic targeting; paramagnetic particle; size 500 nm; therapeutic targeting; tube model; Blood vessels; Drugs; Magnetic fields; Magnetic flux; Magnetic flux density; Magnetic levitation; Magnetic shielding; Neoplasms; Paramagnetic materials; Testing;
Conference_Titel :
Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on
Conference_Location :
Tianjin
Print_ISBN :
978-1-4244-4132-7
Electronic_ISBN :
978-1-4244-4134-1
DOI :
10.1109/BMEI.2009.5304841
