DocumentCode :
2180679
Title :
Feedback regulation of the heat shock response in E. coli
Author :
Kurata, H. ; El-Samad, H. ; Yi, T.-M. ; Khammash, M. ; Doyle, J.
Author_Institution :
Dept. of Biochem. Sci. & Eng., Kyushu Inst. of Technol., Japan
Volume :
1
fYear :
2001
fDate :
2001
Firstpage :
837
Abstract :
Survival of organisms in extreme conditions has necessitated the evolution of stress response networks that detect and respond to environmental changes. Among the extreme conditions that cells must face is the exposure to higher than normal temperatures. In this paper, we propose a detailed biochemical model that captures the dynamical nature of the heat-shock response in Escherichia coli. Using this model, we show that both feedback and feedforward control are utilized to achieve robustness, performance, and efficiency of the response to the heat stress. We discuss the evolutionary advantages that feedback confers to the system, as compared to other strategies that could have been implemented to get the same performance
Keywords :
biocontrol; biothermics; feedback; feedforward; physiological models; robust control; E. coli; Escherichia coli; biochemical model; environmental change detection; environmental change response; evolutionary advantages; feedback control; feedback regulation; feedforward control; heat shock response; organism survival; robustness; stress response networks; Biological system modeling; Electric shock; Feedback; Microorganisms; Organisms; Proteins; RNA; Robust control; Stress control; Temperature control;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Decision and Control, 2001. Proceedings of the 40th IEEE Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
0-7803-7061-9
Type :
conf
DOI :
10.1109/.2001.980210
Filename :
980210
Link To Document :
بازگشت