Functionalized gold nanoparticles for drug delivery

Author

Coelho, S.C. ; Rocha, S. ; Pereira, M.C. ; Coelho, M.A.N. ; Juzenas, P.

Author_Institution

Dept. of Chem. Eng., Univ. of Porto, Porto, Portugal

fYear

2013

fDate

20-23 Feb. 2013

Firstpage

1

Lastpage

4

Abstract

Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.

Keywords

cancer; cellular biophysics; drug delivery systems; drugs; gold; nanomedicine; nanoparticles; radiation therapy; tumours; Au; BTZ; Du-145 cell; X-ray radiation; anticancer drug delivery; anticancer effects; anticancer properties; biological applications; cancer diagnosis; cancer therapy; drug activity; gold nanoparticles; human prostate cancer cells; nanoparticle parameters; proteasome inhibitor; size 24 nm; treatment efficacy; tumor eradication; Chemicals; Drugs; Lead; Nanobioscience; Nanoparticles; Du-145 cells; anticancer drug; cancer therapy; pegylated gold nanoparticles; prostate cancer cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering (ENBENG), 2013 IEEE 3rd Portuguese Meeting in

Conference_Location

Braga

Print_ISBN

978-1-4673-4859-1

Type

conf

DOI

10.1109/ENBENG.2013.6518389

Filename

6518389