Title :
Effect of the normalization template in statistical parametric mapping of PET scans
Author :
Gispert, J.D. ; Pascau, J. ; Reig, S. ; Martinez, R. ; Molina, V. ; Desco, M.
Author_Institution :
Med. lma ng Lab., Hosp. Universitario "Gregorio Maranon", Madrid, Spain
Abstract :
The standard template provided with the statistical software package SPM´99 was originally developed for 15O-H2O PET scans in resting condition with eyes closed. This template is commonly applied regardless of the tracer actually used in the scans being analyzed. This work studies the effect of three different normalization templates in the outcome of the statistical analyses of PET scans, as compared to a reference normalization. Results show that the use of the standard template in adverse conditions-different tracer, different cerebral condition-may introduce errors in the interpretation of the results of the statistical analysis.
Keywords :
brain; medical image processing; positron emission tomography; statistical analysis; 15O-H2O PET scans; H2O; cerebral condition; interpretation errors; medical diagnostic imaging; normalization template effect; nuclear medicine; reference normalization; results interpretation analysis; statistical parametric mapping; statistical software package SPM´99; Biomedical imaging; Eyes; Hospitals; Laboratories; Magnetic resonance imaging; Positron emission tomography; Protocols; Psychiatry; Scanning probe microscopy; Statistical analysis;
Conference_Titel :
Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on
Print_ISBN :
0-7803-7584-X
DOI :
10.1109/ISBI.2002.1029393
