Blood flow measurement system for microcirculation by image correlation method

Author

Tsukada, Kosuke ; Minamitani, Haruyuki ; Sekizuka, Eiichi ; Oshio, Chikara

Author_Institution

Fac. of Sci. & Technol., Keio Univ., Yokohama, Japan

Volume

2

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

684

Abstract

In order to elucidate the function of microcirculation system, which is essential for material transport in tissues and organs, it is very important to know blood flow velocity and its distribution in the microvessels. An image correlation method has been developed for the measurement of red blood cell (RBC) velocity in the microcirculation. Dynamic images of the blood flow are obtained in situ under microscopic observation using a high-speed video system and are processed to measure RBC velocity with a PC system. The results indicate that this system enable to analyze RBC velocity with a high-temporal resolution. This system is applied to RBC velocity measurements in liver and kidney as well as in mesentery. An anti-hypertensive agent is administered to spontaneously hypertensive rats (SHR), and blood flow change is observed. The authors are able to show that this system is effective for pharmacological evaluation

Keywords

biology computing; blood flow measurement; cellular transport; haemorheology; image processing; kidney; liver; microcomputer applications; optical microscopy; velocity measurement; PC system; antihypertensive agent; dynamic images; high-speed video system; image correlation method; material transport; mesentery; microcirculation blood flow measurement system; microvessels; organs; pharmacological evaluation; red blood cell velocity measurement; spontaneously hypertensive rats; tissues; Biological materials; Blood flow; Correlation; Fluid flow measurement; Hypertension; Liver; Microscopy; Rats; Red blood cells; Velocity measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.651927

Filename

651927