Title :
Control of the inflammatory response with poly(trolox ester) antioxidant nanoparticles
Author :
Wardwell, Patricia ; Wattamwar, Paritosh ; Dziubla, Thomas ; Bader, Rebecca
Author_Institution :
Dept. of Biomed. & Chem. Eng., Syracuse Univ., Syracuse, NY, USA
Abstract :
Poly(trolox ester) nanoparticles were screened for anti-inflammatory properties on two different rheumatoid arthritis cell lines. Trolox was polymerized to two different molecular weights and formed into nanoparticles, which were added to cultures of interleukin-1β stimulated MH7A synovial fibroblast cells and macrophage-like U937 cells. Poly(trolox ester) nanoparticles effectively reduced the secretion of pro-inflammatory mediators by both cell types.
Keywords :
biomedical materials; bone; cellular biophysics; diseases; molecular biophysics; nanomedicine; nanoparticles; polymerisation; polymers; proteins; MH7A synovial fibroblast cells; inflammatory response; interleukin-1β; macrophage-like U937 cells; molecular weights; poly(trolox ester) antioxidant nanoparticles; polymerization; pro-inflammatory mediator secretion; rheumatoid arthritis cell lines; Arthritis; Degradation; Diseases; Media; Nanoparticles; Polymers; Stress;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207082
