Title :
Matrices engineered with gradients in rigidity guide stem cell migration and polarize the cytoskeleton
Author :
Raab, M.D. ; Swift, J. ; Discher, D.E.
Author_Institution :
Univ. of Pennsylvania, Philadelphia, PA, USA
Abstract :
Tissues all have characteristic stiffness that can be represented with elastic modulus. The role this may have in guiding cell migration and in particular stem cell migration to areas of fibrotic matrix is not elucidated. Matrix with gradient in rigidity was used to guide stem cell migration as well as polarize the cell´s cytoskeleton.
Keywords :
biomechanics; bone; cell motility; shear modulus; cytoskeleton; elastic modulus; fibrotic matrix; rigidity guide stem cell migration; stiffness; Atomic measurements; Equations; Fluorescence; Heart; Myocardium; Stem cells; Substrates;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207085
