Title :
A model system for determining blastocyst binding mechanics
Author :
Yucha, R.W. ; Jost, M. ; Robertson, N. ; Marcolongo, M.
Author_Institution :
Drexel Univ., Philadelphia, PA, USA
Abstract :
A model system for determining binding mechanics between the blastocyst and uterine endometrium is discussed. We developed 3-dimensional trophospheres as a substitute for blastocysts. Trophospheres detach from sialyl Lewis X under approximately 0.25 dynes of shear force.
Keywords :
biochemistry; cellular biophysics; physiological models; 3D trophospheres; blastocyst binding mechanics; model system; shear force; sialyl Lewis X; uterine endometrium; Approximation methods; Biological system modeling; Fluorescence; Force; Glass; Pregnancy; Surface treatment;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207091
