DocumentCode :
2206963
Title :
Molecular modeling of membrane curvature driven by epsin
Author :
Bradley, Ryan ; Radhakrishnan, Ravi
Author_Institution :
Univ. of Pennsylvania, Philadelphia, PA, USA
fYear :
2012
fDate :
16-18 March 2012
Firstpage :
317
Lastpage :
318
Abstract :
A molecular description of membrane curvature induction by the ENTH domain of the protein epsin has the potential to shed light on clathrin mediated endocytosis and its effect on pathological cell signaling processes. To that end, we are performing coarse-grained and all-atom molecular dynamics simulations of membrane remodeling by epsin. Coarse-grained simulations are used to characterize the local stress distribution throughout the membrane, yielding a microscopic picture of the induced curvature field, the additive effects of multiple epsins, and the role of surface tension in mediating epsin-membrane interactions.
Keywords :
biomembranes; internal stresses; molecular biophysics; molecular configurations; molecular dynamics method; proteins; surface tension; all-atom molecular dynamics simulations; clathrin mediated endocytosis; coarse-grained simulations; epsin-membrane interactions; local stress distribution; membrane curvature induction; molecular modeling; pathological cell signaling processes; protein epsin; surface tension; Biological system modeling; Biomembranes; Computational modeling; Force; Lipidomics; Proteins; Stress;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
ISSN :
2160-7001
Print_ISBN :
978-1-4673-1141-0
Type :
conf
DOI :
10.1109/NEBC.2012.6207092
Filename :
6207092
Link To Document :
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