Title :
Myocardial perfusion imaging with a correlated X-ray CT and SPECT system: an animal study
Author :
Kalki, Kathrin ; Brown, J. Keeiian ; Blankespoor, S.C. ; Hasegawa, Bruce H. ; Dae, Michael W. ; Chin, Michael ; Stillson, Carol A.
Author_Institution :
Phys. Res. Lab., California Univ., San Francisco, CA, USA
Abstract :
We have performed a quantitative SPECT study in a porcine model of myocardial perfusion with the correlated X-ray CT transmission and SPECT emission (ETCT) system developed at UCSF. Pixel values in the reconstructed SPECT images were calibrated in units of activity concentration and compared with the activity concentration determined from corresponding excised myocardial tissue samples. An object specific attenuation map was derived by linear scaling from the X-ray CT. An MLEM algorithm with regularization was used to determine mean and maximum pixel values for ROI´s in the myocardial SPECT images. The use of the maximum pixel value did not sufficiently compensate for contrast degradation due to partial volume errors. A separate measurement of the myocardial wall thickness was used to adequately correct for partial volume errors
Keywords :
cardiology; computerised tomography; correlation methods; image reconstruction; image resolution; medical image processing; muscle; single photon emission computed tomography; ETCT; MLEM algorithm; SPECT emission system; activity concentration; animal study; contrast degradation; correlated X-ray CT; excised myocardial tissue samples; linear scaling; myocardial perfusion imaging; myocardial wall thickness; object specific attenuation map; partial volume errors; pixel values; porcine model; quantitative SPECT study; reconstructed SPECT images; regularization; Attenuation; Computed tomography; Degradation; Image reconstruction; Myocardium; Optical imaging; Pixel; Thickness measurement; Volume measurement; X-ray imaging;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference Record, 1995., 1995 IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-3180-X
DOI :
10.1109/NSSMIC.1995.510424
