• DocumentCode
    2217821
  • Title

    Evaluating the effects of chronic MDMA abuses on cerebral metabolism using proton magnetic resonance spectroscopy (1H-MRS)

  • Author

    Liu, Wei-Yin ; Chen, Po-Chou ; Chang, Chen ; Chu, Woei-Chyn

  • Author_Institution
    Inst. of Biomed. Eng., Nat. Yang-Ming Univ., Taipei
  • fYear
    2008
  • fDate
    30-31 May 2008
  • Firstpage
    575
  • Lastpage
    577
  • Abstract
    MDMA is a widely abused amphetamine derivative that alters serotonin (5-HT) release via the reverse serotonin re-uptake transporter (SERT) mechanism. This phenomenon leads to neurotoxicity in the synaptic clefts, especially in the striatum. As the major function of the striatum is planning and modulating movement pathways and cognitive processes, the objective of this study is to investigate the neuronal viability of chronic MDMA-influenced rats, as well as the effect of re-challenged MDMA.
  • Keywords
    biomagnetism; biomedical MRI; biomedical measurement; brain; drugs; neurophysiology; 3,4-methylenedioxymethamphetamine; amphetamine derivative; cerebral metabolism; chronic MDMA abuses; chronic MDMA-influenced rats; cognitive processes; neuronal viability; neurotoxicity; proton magnetic resonance spectroscopy; serotonin re-uptake transporter; serotonin release; striatum; synaptic clefts; Animals; Biochemistry; Drugs; Information technology; Magnetic resonance; Neurons; Protocols; Protons; Rats; Spectroscopy;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Information Technology and Applications in Biomedicine, 2008. ITAB 2008. International Conference on
  • Conference_Location
    Shenzhen
  • Print_ISBN
    978-1-4244-2254-8
  • Electronic_ISBN
    978-1-4244-2255-5
  • Type

    conf

  • DOI
    10.1109/ITAB.2008.4570575
  • Filename
    4570575
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2217821