• DocumentCode
    2218258
  • Title

    A faster algorithm for gene-duplication problem based on rSPR local search

  • Author

    Zhang, Jian ; Zhu, Daming

  • Author_Institution
    Sch. of Comput. Sci. & Technol., Shandong Univ., Jinan, China
  • Volume
    5
  • fYear
    2010
  • fDate
    20-22 Aug. 2010
  • Abstract
    The gene-duplication problem is to infer a species tree from a collection of gene trees. As we know, this problem is NP-hard and thus requires efficient heuristics. Existing heuristics for this problem performs a stepwise search of the tree space which consists of all potential species trees. Each step in heuristics is guided by an exact solution to an instance of local search problem. The local search problem is to find an optimal species tree in the tree space. Computing the mapping for gene trees and a species tree is a necessary step in the local search problem. In this paper, we give an improved algorithm to determine the mapping between gene trees and a species tree in the gene-duplication problem based on the rooted subtree pruning and regrafting (rSPR) operation. This algorithm eliminates some redundant calculations and is faster than former algorithms.
  • Keywords
    biology computing; computational complexity; genetics; genomics; optimisation; tree searching; NP-hard; gene tree; gene-duplication problem; local search problem; rSPR; regrafting; rooted subtree pruning; stepwise search; tree space; tree species; gene duplication; gene tree; rSPR; species tree; the least common ancestor;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Advanced Computer Theory and Engineering (ICACTE), 2010 3rd International Conference on
  • Conference_Location
    Chengdu
  • ISSN
    2154-7491
  • Print_ISBN
    978-1-4244-6539-2
  • Type

    conf

  • DOI
    10.1109/ICACTE.2010.5579138
  • Filename
    5579138