DocumentCode
2218258
Title
A faster algorithm for gene-duplication problem based on rSPR local search
Author
Zhang, Jian ; Zhu, Daming
Author_Institution
Sch. of Comput. Sci. & Technol., Shandong Univ., Jinan, China
Volume
5
fYear
2010
fDate
20-22 Aug. 2010
Abstract
The gene-duplication problem is to infer a species tree from a collection of gene trees. As we know, this problem is NP-hard and thus requires efficient heuristics. Existing heuristics for this problem performs a stepwise search of the tree space which consists of all potential species trees. Each step in heuristics is guided by an exact solution to an instance of local search problem. The local search problem is to find an optimal species tree in the tree space. Computing the mapping for gene trees and a species tree is a necessary step in the local search problem. In this paper, we give an improved algorithm to determine the mapping between gene trees and a species tree in the gene-duplication problem based on the rooted subtree pruning and regrafting (rSPR) operation. This algorithm eliminates some redundant calculations and is faster than former algorithms.
Keywords
biology computing; computational complexity; genetics; genomics; optimisation; tree searching; NP-hard; gene tree; gene-duplication problem; local search problem; rSPR; regrafting; rooted subtree pruning; stepwise search; tree space; tree species; gene duplication; gene tree; rSPR; species tree; the least common ancestor;
fLanguage
English
Publisher
ieee
Conference_Titel
Advanced Computer Theory and Engineering (ICACTE), 2010 3rd International Conference on
Conference_Location
Chengdu
ISSN
2154-7491
Print_ISBN
978-1-4244-6539-2
Type
conf
DOI
10.1109/ICACTE.2010.5579138
Filename
5579138
Link To Document