Title :
Effects of the Transcriptional Rate on the Genetic Positive - Negative Feedback Regulation System
Author :
Wang, Jiuyun ; Ruan, Guolong ; Li, Zhongming
Author_Institution :
Sch. of Electron. & Inf. Eng., Xianning Univ., Xianning, China
Abstract :
Based on the kinetic model of genetic positive - negative feedback regulation system, We have investigated that the transcriptional rate can regulate genetic regulation system. Brief perturbations can elicit oscillations for a low steady state in positive and negative feedback loop, and the amplitude of oscillations is varying with changing of the transcriptional rate. Furthermore, the effects of fluctuations in the transcriptional rate have been clarified that the fluctuations occur oscillations through numerical computation.
Keywords :
biology computing; genetics; genetic modelling; genetic positive-negative feedback regulation system; negative feedback loop; numerical computation; positive feedback loop; transcriptional rate; Biological system modeling; Biological systems; Fluctuations; Genetic engineering; Kinetic theory; Negative feedback; Negative feedback loops; Proteins; Stochastic resonance; Switches;
Conference_Titel :
Information Science and Engineering (ICISE), 2009 1st International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-4909-5
DOI :
10.1109/ICISE.2009.535
