A quantitative description of fluorescein transdermal transport by electroporation

In this paper, quantitative relationship of the drug permeable flux to pass skin with pathway consistence on epidermis in side-by-side permeation chamber is described by drug permeation model. It is considered that pathway conductance for drug through skin is regulated by activation and inactivation factors. From completed passive (control) and electrical pulse (experiments) experiments with fluorescein isothiocyanate-dextran (FD), the results show that theoretical curves of pathway conductance on epidermis are fitted very well with the data from these experiments. So the conclusion is that initial activation variable (m₀) increases with the initial drug flux in experiment, and the maximum of skin pathway conductance Kmacr_T can reflect the pulsed energy applied in the experiment at some extent. And this model may be very important for analysis of property of pathway conductance of drug transport through skin.