Title :
Probing Control for PWL Approximation of Nonlinear Cellular Growth
Author :
Mojica, Eduardo ; Gauthier, Alain ; Rakoto-Ravalontsalama, Naly
Author_Institution :
Ecole des Mines de Nantes, Nantes
Abstract :
In this paper we develop and improve a piecewise-linear approximations of nonlinear cellular growth using orthonormal canonical piecewise linear functions (Julian et al., 2000), and it is tested by a probing control strategy (Akesson et al.)for the feed rate. The work is with the mammalian cells BHK (baby hamster kidney) in bioreactor in batch, fed-batch and continuous mode operation. Preliminary results show that this piecewise linear approximation is well suited for modeling such nonlinear dynamics.
Keywords :
approximation theory; batch processing (industrial); bioreactors; cellular biophysics; nonlinear dynamical systems; piecewise linear techniques; Baby Hamster Kidney; bioreactor; fed-batch continuous mode operation; mammalian cells; nonlinear cellular growth; nonlinear dynamic system; orthonormal canonical piecewise linear function; piecewise-linear approximation; probing control strategy; Amino acids; Biological system modeling; Bioreactors; Cells (biology); Control systems; Feeds; Nonlinear control systems; Open loop systems; Piecewise linear approximation; Piecewise linear techniques; Bioreactor; nonlinear dynamics; piecewise-linear (PWL) models;
Conference_Titel :
Control Applications, 2007. CCA 2007. IEEE International Conference on
Conference_Location :
Singapore
Print_ISBN :
978-1-4244-0442-1
Electronic_ISBN :
978-1-4244-0443-8
DOI :
10.1109/CCA.2007.4389220
