Models of Functional Enzyme Membranes for Hemo-Sensor Design

Functional membranes can be used to develop hemo-sensors (for urea, creatinine, etc.) based on pH response devices. In this work, we present a model-based approach to design and fabricate functional enzyme membranes. Specifically, through model development and simulation, membrane matrix materials are selected, and the membrane design parameters are optimized. The membrane material selection and design are based on thermodynamic modeling of the Donnan equilibrium and membrane swelling. And the optimization of membrane parameters is based on a dynamic model of the sensing process of an ISFET based hemo-sensor coated with a functional enzyme membrane. The dynamic models of the sensing process are important for the real time control applications using such biosensors.