DocumentCode
2221955
Title
Characterisation of chlorpromazine binding to lipid bilayer membranes
Author
Nussio, Matthew R. ; Sykes, Matthew J. ; Miners, John O. ; Shapter, Joseph G.
Author_Institution
Sch. of Chem., Phys. & Earth Sci., Flinders Univ., Adelaide, SA
fYear
2006
fDate
3-7 July 2006
Abstract
With the aid of atomic force microscopy (AFM) and surface plasmon resonance (SPR), the interaction of chlorpromazine (CPZ) with phosphatidylcholine bilayer membranes was investigated. The interaction of CPZ had inherent effects on the transition temperature (TM), and hence, fluidity of DMPC phospholipid membranes. It was discovered that CPZ intercalates within the membrane bilayers to form a drug/phospholipid complex.
Keywords
atomic force microscopy; drugs; lipid bilayers; surface plasmon resonance; atomic force microscopy; chlorpromazine binding; drug/phospholipid complex; lipid bilayer membranes; phosphatidylcholine bilayer membranes; phospholipid membranes; surface plasmon resonance; transition temperature; Atomic force microscopy; Biomembranes; Biosensors; Drugs; Instruments; Lipidomics; Plasmons; Proteins; Resonance; Temperature;
fLanguage
English
Publisher
ieee
Conference_Titel
Nanoscience and Nanotechnology, 2006. ICONN '06. International Conference on
Conference_Location
Brisbane, Qld.
Print_ISBN
1-4244-0453-3
Electronic_ISBN
1-4244-0453-3
Type
conf
DOI
10.1109/ICONN.2006.340603
Filename
4143383
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