Title :
Electrochemical treatment of localized tumors with direct current
Author :
Chou, C.K. ; Vora, N. ; Li, J.R. ; Wang, W. ; Yen, Y. ; Ren, R.L. ; McDougall, J.A. ; Stand, C. ; Zhou, B.S. ; Weiss, L.
Author_Institution :
Div. of Radiat. Onocology, City of Hope Nat. Med. Center, Duarte, CA, USA
Abstract :
To develop cancer electrochemical treatment (ECT) in the United States, we have conducted basic studies and started a Phase I clinical trial. Our in vivo preliminary results indicate that ECT is effective on RIF-I mouse tumor and rat fibrosarcomas. In the in vitro study ECT clearly demonstrated dose-dependent human oral carcinoma KB cell growth inhibition by colony-forming assay. We have started an animal study to resolve the ECT methodological problems for rat breast cancer. Meanwhile, we began a clinical trial treating patients with recurrent superficial measurable malignant tumors. Our goal is to make ECT a useful alternative method for treating localized tumors
Keywords :
bioelectric phenomena; biomedical electrodes; cancer; cellular biophysics; electrochemistry; patient treatment; tumours; Phase I clinical trial; RIF-I mouse tumor; United States; animal study; basic studies; cancer; clinical trial; colony-forming assay; direct current; dose-dependent human oral carcinoma KB cell growth inhibition; electrochemical treatment; in vitro study; in vivo preliminary results; localized tumors; rat breast cancer; rat fibrosarcomas; recurrent superficial measurable malignant tumors; Animals; Breast cancer; Breast neoplasms; Clinical trials; Electrical capacitance tomography; Humans; In vitro; In vivo; Medical treatment; Mice;
Conference_Titel :
Bioelectromagnetism, 1998. Proceedings of the 2nd International Conference on
Conference_Location :
Melbourne, Vic.
Print_ISBN :
0-7803-3867-7
DOI :
10.1109/ICBEM.1998.666374
