Closed-loop control of seizures in a rat model of absence epilepsy using the BioMEA™ system

Author

Sandrine, Saillet ; Guillaume, Charvet ; Sadok, Gharbi ; Antoine, Depaulis ; Régis, Guillemaud ; Olivier, David

Author_Institution

GIN, Grenoble, France

fYear

2009

fDate

April 29 2009-May 2 2009

Firstpage

693

Lastpage

696

Abstract

This preliminary study constitutes a proof of concept for seizure-triggered neuromodulation in a genetic rat model of absence epilepsy (GAERS) using the BioMEAtrade system. BioMEAtrade is a 256-channel MEA system with integrated electronics (ASIC) allowing simultaneous recording and stimulation of neural networks in vitro. It is based on parallel architecture of 64-channel ASICs with recording and stimulation capabilities for each channel. Here, we show that BioMEAtrade can also be used to develop adaptive protocols of neurostimulation in vivo. In epileptic rats, a seizure detection algorithm delivered online command to BioMEAtrade for bilateral stimulation of the substantia nigra pars reticulata which aborted spike-and-wave discharges in many instances, within 1 second following seizure onset.

Keywords

adaptive systems; application specific integrated circuits; biomedical electronics; medical computing; medical control systems; neural nets; neuromuscular stimulation; parallel architectures; protocols; seizure; 256-channel MEA system; 64-channel ASICs; BioMEA system; absence epilepsy; adaptive protocols; bilateral stimulation; closed-loop control; integrated electronics; neural networks; parallel architecture; rat model; recording; seizure-triggered neuromodulation; spike-and-wave discharges; substantia nigra pars reticulata; time 1 s; Application specific integrated circuits; Detection algorithms; Epilepsy; Genetics; In vitro; In vivo; Neural networks; Parallel architectures; Protocols; Rats; Integrated electronics (ASIC); animal model; closed-loop stimulation; electroencephalography; epilepsy; signal processing;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2009. NER '09. 4th International IEEE/EMBS Conference on

Conference_Location

Antalya

Print_ISBN

978-1-4244-2072-8

Electronic_ISBN

978-1-4244-2073-5

Type

conf

DOI

10.1109/NER.2009.5109391

Filename

5109391