Title :
SH-SAW biosensor based on pH change
Author :
Kondoh, Jun ; Matsui, Yusuke ; Shiokawa, Shigeki
Author_Institution :
Fac. of Eng., Shizuoka Univ., Hamamatsu
fDate :
31 Oct-3 Nov 1993
Abstract :
This paper describes an enzyme-immobilized biosensor using a surface acoustic wave (SAW) device fabricated on 36° rotated Y-cut, X-propagating LiTaO3. The sensing wave on the substrate is a predominantly shear-horizontal-mode SAW (SH-SAW) and is affected by a strong acoustoelectric interaction between the electric field and electric properties of the materials in the adjacent liquid. As an example of an electric property, the pH change associated with an enzyme reaction leads to measurable perturbation in the wave-propagation characteristics. Taking advantage of this phenomenon, we realized a SAW biosensor which consists of an immobilized urease film on the surface. Also, highly sensitive detection for the urea solution was obtained in our preliminary experiments
Keywords :
acoustoelectric transducers; biosensors; surface acoustic wave devices; ultrasonic devices; LiTaO3; SH-SAW biosensor; Y-cut LiTaO3; acoustoelectric interaction; enzyme-immobilized biosensor; pH change; shear-horizontal-mode SAW; urea solution; urease film; Acoustic sensors; Acoustic signal detection; Biochemistry; Biosensors; Chemical and biological sensors; Electric potential; Electromechanical sensors; Metallization; Permittivity; Surface acoustic waves;
Conference_Titel :
Ultrasonics Symposium, 1993. Proceedings., IEEE 1993
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2012-3
DOI :
10.1109/ULTSYM.1993.339472
