Title :
Complete evaluation of conformational MW effects on ACh channels with parallel computing
Author_Institution :
Istituto di Elettronica, Perugia Univ., Italy
Abstract :
The authors present here a parallel implementation and optimization of a Markov model simulating the acetylcholine-receptor (ACh) channel response to 2.45 GHz fields. It overcomes the limitations of a previous implementation, allowing a complete understanding of the simulated phenomenon. The main experimentally observed effects of microwaves on ACh channels are theoretically explained, and an energetical mapping of ACh conformational changes achieved.
Keywords :
Markov processes; biological effects of microwaves; biology computing; biomembrane transport; biomolecular effects of radiation; cellular effects of radiation; neurophysiology; parallel processing; physiological models; proteins; 2.45 GHz; Markov model; acetylcholine-receptor channel response; cellular radiation biology; conformational microwave effects; energetical mapping; ionic protein channels; model optimization; molecular radiation biology; parallel computing; Biological system modeling; Biological systems; Biomembranes; Cells (biology); Computational modeling; Electromagnetic fields; Frequency; Parallel processing; Proteins; Stochastic processes;
Conference_Titel :
Microwave Symposium Digest, 1996., IEEE MTT-S International
Conference_Location :
San Francisco, CA, USA
Print_ISBN :
0-7803-3246-6
DOI :
10.1109/MWSYM.1996.511220
