Title :
Optimal control for combination therapy in cancer
Author :
Ledzewicz, Urszula ; Schättler, Heinz ; Onofrio, Alberto D.
Author_Institution :
Dept. of Math, & Stat., Southern Illinois Univ. Edwardsville, Edwardsville, IL, USA
Abstract :
A mathematical model for the scheduling of angiogenic inhibitors in combination with a killing agent is considered as an optimal control problem. Initial results on the structure of optimal controls are derived.
Keywords :
cancer; medical control systems; optimal control; angiogenic inhibitor; cancer; combination therapy; killing agent; optimal control; Biological system modeling; Cancer; Immune system; In vivo; Inhibitors; Mathematical model; Medical treatment; Neoplasms; Oncology; Optimal control;
Conference_Titel :
Decision and Control, 2008. CDC 2008. 47th IEEE Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-3123-6
Electronic_ISBN :
0191-2216
DOI :
10.1109/CDC.2008.4738880
