Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically-targeted cancer therapy and diagnosis using magnetic resonance imaging

Author

Seo, Sungbaek ; Yang, Jaemoon ; Hyung, Woochan ; Cho, Eun-Jin ; Song, Yong Jin ; Yoon, Ho-Geun ; Suh, Jin-Suck ; Huh, Yong-Min ; Haam, Seungjoo

Author_Institution

Grad. Program for Nanomedical Sci., Yonsei Univ., Seoul

fYear

2007

fDate

26-31 Aug. 2007

Firstpage

1

Lastpage

2

Abstract

Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis using magnetic resonance imaging (MRI). The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated to assess the therapeutic potential of the MPDCs.

Keywords

biomedical NMR; cancer; drug delivery systems; nanobiotechnology; cancer diagnosis; drug loading efficiency; magnetic mobility; magnetic resonance imaging; multifunctional magnetic polycation drug carriers; multifunctional nanodrug carrier; release kinetics; simultaneous magnetically-targeted cancer therapy; Cancer; Drugs; Educational institutions; Magnetic fields; Magnetic resonance imaging; Medical treatment; Nanocrystals; Nanoparticles; Saturation magnetization; Solvents;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics - Pacific Rim, 2007. CLEO/Pacific Rim 2007. Conference on

Conference_Location

Seoul

Print_ISBN

978-1-4244-1173-3

Electronic_ISBN

978-1-4244-1174-0

Type

conf

DOI

10.1109/CLEOPR.2007.4391370

Filename

4391370