Title :
Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically-targeted cancer therapy and diagnosis using magnetic resonance imaging
Author :
Seo, Sungbaek ; Yang, Jaemoon ; Hyung, Woochan ; Cho, Eun-Jin ; Song, Yong Jin ; Yoon, Ho-Geun ; Suh, Jin-Suck ; Huh, Yong-Min ; Haam, Seungjoo
Author_Institution :
Grad. Program for Nanomedical Sci., Yonsei Univ., Seoul
Abstract :
Novel multifunctional magnetic polycation drug carriers (MPDCs) were synthesized to provide simultaneous magnetically targeted cancer therapy and diagnosis using magnetic resonance imaging (MRI). The MPDCs demonstrated ultra-sensitivity via MRI and sufficient magnetic mobility under an external magnetic field. Drug loading efficiency and release kinetics were also investigated to assess the therapeutic potential of the MPDCs.
Keywords :
biomedical NMR; cancer; drug delivery systems; nanobiotechnology; cancer diagnosis; drug loading efficiency; magnetic mobility; magnetic resonance imaging; multifunctional magnetic polycation drug carriers; multifunctional nanodrug carrier; release kinetics; simultaneous magnetically-targeted cancer therapy; Cancer; Drugs; Educational institutions; Magnetic fields; Magnetic resonance imaging; Medical treatment; Nanocrystals; Nanoparticles; Saturation magnetization; Solvents;
Conference_Titel :
Lasers and Electro-Optics - Pacific Rim, 2007. CLEO/Pacific Rim 2007. Conference on
Conference_Location :
Seoul
Print_ISBN :
978-1-4244-1173-3
Electronic_ISBN :
978-1-4244-1174-0
DOI :
10.1109/CLEOPR.2007.4391370
