Title :
Highly selective single-nucleotide polymorphism detection with optofluidic ring resonator lasers
Author :
Sun, Yuze ; Fan, Xudong
Author_Institution :
Biomed. Eng. Dept., Univ. of Michigan, Ann Arbor, MI, USA
Abstract :
Optofluidic ring resonator microlasers in conjunction with molecular beacons are used for intracavity detection of DNA single-nucleotide polymorphism. A discrimination ratio of 100 is achieved between the target DNA and single-base-mismatched DNA.
Keywords :
DNA; bioMEMS; biosensors; laser beam applications; microcavity lasers; molecular biophysics; molecular configurations; polymorphism; DNA single-nucleotide polymorphism; discrimination ratio; intracavity detection; microlasers; molecular beacons; optofluidic ring resonator lasers; single-base-mismatched DNA; DNA; Fluorescence; Laser excitation; Optical ring resonators; Ring lasers; Sensors;
Conference_Titel :
Lasers and Electro-Optics (CLEO), 2011 Conference on
Conference_Location :
Baltimore, MD
Print_ISBN :
978-1-4577-1223-4
