Towards automated handling of biomaterials for nano-biosensor fabrication

The integration of biomaterials into micro-systems or sensors can improve the properties of such systems or even lead to the development of novel innovative systems. A key problem is the development and realization of handling and manipulation methods as enabling technology for their micro-nano-integration. In this paper, novel methods for the manipulation and handling of DNA to design nanoelectric parts and to solve packaging issues at the nanoscale are presented. Concerning DNA handling, first results of a movement for the fine tuning of the DNA position and for movement of complete strands are presented. Furthermore, an AFM-based technique for the structuring of biosensor biocomponents (e.g. antibody-antigene assays) for automated and mobile diagnostic systems usable in medicine and research is presented. For the optimization of methods to handle long nanoscopic objects, the current state of our research to develop the new lateral vibration AFM mode is presented.