• DocumentCode
    2249903
  • Title

    Vibrational photoacoustic microscopy for depth-resolved bond-selective imaging of tissues and organisms

  • Author

    Wang, Han-Wei ; Chai, Ning ; Hu, Song ; Dou, Wei ; Umulis, David ; Wang, Lihong V. ; Sturek, Michael ; Lucht, Robert ; Cheng, Ji-Xin

  • Author_Institution
    Weldon Sch. of Biomed. Eng., Purdue Univ., West Lafayette, IN, USA
  • fYear
    2011
  • fDate
    1-6 May 2011
  • Firstpage
    1
  • Lastpage
    2
  • Abstract
    We realize vibrational photoacoustic microscopy (VPA) using molecular excitation of overtone vibration and acoustic detection of the resultant pressure transients. We demonstrate 3-D VPA imaging of lipid-rich atherosclerotic plaques and lipid bodies in living Drosophila larvae by exciting 2nd overtone of the CH bond stretch around 8300 cm-1. Depth-resolved spectral analysis and a penetration depth of several mm are available.
  • Keywords
    bioacoustics; biological tissues; biomedical optical imaging; photoacoustic effect; 3D VPA imaging; Drosophila larvae; biological tissues; bond stretch; depth-resolved bond-selective imaging; lipid-rich atherosclerotic plaque; molecular excitation; organisms; vibrational photoacoustic microscopy; Absorption; Atherosclerosis; Biology; Lipidomics; Microscopy; Vibrations;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Lasers and Electro-Optics (CLEO), 2011 Conference on
  • Conference_Location
    Baltimore, MD
  • Print_ISBN
    978-1-4577-1223-4
  • Type

    conf

  • Filename
    5951012
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2249903