Title :
Intracellular photodisruption with targeted silver/dendrimer nanocomposites and femtosecond lasers
Author :
Tse, Christine ; Lesniak, Wojciech ; Zohdy, Marwa J. ; Balogh, Lajos ; Donnell, Matthew O. ; Norris, Theodore B. ; Ye, Jing Yong
Author_Institution :
Dept. of Biomed. Eng., Univ. of Michigan, Ann Arbor, MI
Abstract :
Folate-targeted silver/dendrimer nanocomposites were developed and tested on a human oral epidermoid cancer cell line. We observed a reduced threshold in targeted cells for femtosecond-laser-induced optical breakdown, which leads to selective photodisruption of cancer cells.
Keywords :
biological effects of laser radiation; cancer; cellular effects of radiation; high-speed optical techniques; laser applications in medicine; nanocomposites; silver; femtosecond lasers; human oral epidermoid cancer cell; intracellular photodisruption; optical breakdown; silver/dendrimer nanocomposites; Absorption; Biomedical optical imaging; Cancer; Electric breakdown; Fluorescence; Nanobioscience; Nanocomposites; Nonlinear optics; Silver; Ultrafast optics; (170.1020) Ablation of tissue; (170.7160) Ultrafast technology; (170.7180) Ultrasound diagnostics;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
