Title :
Coupling effects in networks of cyclic negative feedback systems
Author :
Lanza, Valentina ; Corinto, Fernando ; Gilli, Marco
Author_Institution :
Dept. of Phys., Politec. di Torino, Torino, Italy
Abstract :
Negative feedback control loops are widely used in numerous models of periodic phenomena occurring in systems biology, since they give rise to sustained oscillations. In particular, the possible coexistence of different attractors permits to suitably describe the differentiating processes arising in the cell. The aim of this work is to study coupled systems of such kind through spectral techniques, in order to characterize the various complex dynamical behaviors that can emerge due to the couplings.
Keywords :
biology; feedback; large-scale systems; time-varying systems; complex dynamical behavior; coupling effects; cyclic negative feedback systems; negative feedback control loop; periodic phenomena; spectral techniques; systems biology; Biological system modeling; Circadian rhythm; Clocks; Feedback control; Limit-cycles; Nearest neighbor searches; Negative feedback; Negative feedback loops; Physics; Systems biology;
Conference_Titel :
Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on
Conference_Location :
Taipei
Print_ISBN :
978-1-4244-3827-3
Electronic_ISBN :
978-1-4244-3828-0
DOI :
10.1109/ISCAS.2009.5117890
