Micro and nanopore structures for biological applications

Author

Austin, Robert H. ; Carlson, Robert H. ; Chan, Shirley S. ; Knight, James ; Turner, Stephen ; Craighead, Harold

Author_Institution

Princeton Univ., NJ, USA

Volume

2

fYear

1997

fDate

16-19 Jun 1997

Firstpage

1303

Abstract

The power of micromachining of structures in silicon is now begining to be fully exploited in biotechnology. The author gives three examples of what kinds of structures can be made and their applications. (1) The development of our understanding of the parameters necessary for successful separation and fabrication of sufficiently small structures for sequencing. (2) Cell fractionation from whole blood. (3) Protein folding. This is a new project. The idea is to use a combination of micron-scale structures, hydrodynamic focusing and diffusional mixing to achieve microsecond mixing times of renaturing solvents with a denatured protein solution

Keywords

biological techniques; biosensors; biotechnology; blood; cellular biophysics; elemental semiconductors; micromachining; micromechanical devices; molecular biophysics; nanotechnology; proteins; silicon; Si; biological applications; biotechnology; cell fractionation; denatured protein solution; diffusional mixing; micromachining; nanopore structures; protein folding; sequencing; Biotechnology; Blood; Cells (biology); Fabrication; Fractionation; Hydrodynamics; Micromachining; Nanoporous materials; Protein engineering; Silicon;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on

Conference_Location

Chicago, IL

Print_ISBN

0-7803-3829-4

Type

conf

DOI

10.1109/SENSOR.1997.635475

Filename

635475