DocumentCode :
2256575
Title :
Micro and nanopore structures for biological applications
Author :
Austin, Robert H. ; Carlson, Robert H. ; Chan, Shirley S. ; Knight, James ; Turner, Stephen ; Craighead, Harold
Author_Institution :
Princeton Univ., NJ, USA
Volume :
2
fYear :
1997
fDate :
16-19 Jun 1997
Firstpage :
1303
Abstract :
The power of micromachining of structures in silicon is now begining to be fully exploited in biotechnology. The author gives three examples of what kinds of structures can be made and their applications. (1) The development of our understanding of the parameters necessary for successful separation and fabrication of sufficiently small structures for sequencing. (2) Cell fractionation from whole blood. (3) Protein folding. This is a new project. The idea is to use a combination of micron-scale structures, hydrodynamic focusing and diffusional mixing to achieve microsecond mixing times of renaturing solvents with a denatured protein solution
Keywords :
biological techniques; biosensors; biotechnology; blood; cellular biophysics; elemental semiconductors; micromachining; micromechanical devices; molecular biophysics; nanotechnology; proteins; silicon; Si; biological applications; biotechnology; cell fractionation; denatured protein solution; diffusional mixing; micromachining; nanopore structures; protein folding; sequencing; Biotechnology; Blood; Cells (biology); Fabrication; Fractionation; Hydrodynamics; Micromachining; Nanoporous materials; Protein engineering; Silicon;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Solid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-3829-4
Type :
conf
DOI :
10.1109/SENSOR.1997.635475
Filename :
635475
Link To Document :
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