Title :
A hybrid thin-film/CMOS fluorescence contact imager
Author :
Singh, Ritu Raj ; Ho, Derek ; Nilchi, Alireza ; Genov, Roman ; Gulak, Glenn
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON, Canada
Abstract :
A hybrid thin film/CMOS microsystem for fluorescence contact imaging is presented. The microsystem integrates a high-performance optical filter and a 128times128-pixel imager fabricated in a 0.35 mum technology. The thin-film filter is fabricated and characterized prior to assembly. Its optical density (OD) is over 6.0 at the wavelength of interest. The performance of the microsystem is experimentally validated by imaging conventional Cy3 fluorophore spots using a low-cost pen-sized laser. The emission intensity as a function of fluorophore concentration is measured with the estimated sensitivity of 20 fluorophore/ mum2.
Keywords :
CMOS image sensors; integrated optoelectronics; optical filters; optical images; optical sensors; thin film circuits; CMOS fluorescence contact imager; Cy3 fluorophore spot; fluorophore concentration; high-performance optical filter; hybrid thin film-CMOS microsystem; low-cost pen-sized laser; optical density; size 0.35 mum; Assembly; CMOS technology; Fluorescence; Optical films; Optical filters; Optical imaging; Optical sensors; Stimulated emission; Transistors; Wavelength measurement;
Conference_Titel :
Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on
Conference_Location :
Taipei
Print_ISBN :
978-1-4244-3827-3
Electronic_ISBN :
978-1-4244-3828-0
DOI :
10.1109/ISCAS.2009.5118293
