Circadian rhythms recovery based on slide mode controller

Disrupting the circadian rhythms will cause health problems such as sleep disorders, memory disorders and obesity. Finding the suitable external stimulation to synchronize a model with a desired phase is a biologically significant issue. The phase control of circadian rhythms for Drosophila is considered from control engineering viewpoint in this paper. If all parameters of the model are known, we can use the feedback linearization to design a tracking controller for the phase control. However, in practice, parameters uncertainties always exist. To deal with this problem, a slide-mode controller is proposed for the phase tracking control of circadian rhythms. The simulation results show the effectiveness of the proposed method.