DocumentCode
2272484
Title
The ovariectomized mouse as a model for osteoporosis
Author
Galie, Theresa L. ; Lynch, Maureen E. ; Main, Russell P. ; Van der Meulen, Marjolein C H
Author_Institution
Cornell Univ., Ithaca, NY, USA
fYear
2010
fDate
26-28 March 2010
Firstpage
1
Lastpage
2
Abstract
Bone loss in the spine due to estrogen withdrawal following menopause leads to reduced mechanical strength and ultimately fracture in women. Ovariectomized mice may serve as an appropriate model for Type II osteoporosis, but have not been fully characterized. This study relates whole bone mechanical properties to morphological changes in mouse vertebrae following estrogen withdrawal. The development and validation of mouse models for Type II osteoporosis will allow genetic influences to be examined in the future.
Keywords
biomechanics; bone; diseases; fracture; mechanical strength; physiological models; bone loss; estrogen withdrawal; fracture; mechanical properties; mechanical strength; menopause; mouse models; mouse vertebrae; ovariectomized mouse; spine; type II osteoporosis; Bones; Costs; Genetics; Mechanical factors; Mice; Morphology; Osteoporosis; Spine; Surgery; System testing;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location
New York, NY
Print_ISBN
978-1-4244-6879-9
Type
conf
DOI
10.1109/NEBC.2010.5458136
Filename
5458136
Link To Document