Title :
The ovariectomized mouse as a model for osteoporosis
Author :
Galie, Theresa L. ; Lynch, Maureen E. ; Main, Russell P. ; Van der Meulen, Marjolein C H
Author_Institution :
Cornell Univ., Ithaca, NY, USA
Abstract :
Bone loss in the spine due to estrogen withdrawal following menopause leads to reduced mechanical strength and ultimately fracture in women. Ovariectomized mice may serve as an appropriate model for Type II osteoporosis, but have not been fully characterized. This study relates whole bone mechanical properties to morphological changes in mouse vertebrae following estrogen withdrawal. The development and validation of mouse models for Type II osteoporosis will allow genetic influences to be examined in the future.
Keywords :
biomechanics; bone; diseases; fracture; mechanical strength; physiological models; bone loss; estrogen withdrawal; fracture; mechanical properties; mechanical strength; menopause; mouse models; mouse vertebrae; ovariectomized mouse; spine; type II osteoporosis; Bones; Costs; Genetics; Mechanical factors; Mice; Morphology; Osteoporosis; Spine; Surgery; System testing;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458136
