Visual fly-throughs of rat osteogenic sarcoma by optical coherence imaging

Summary from only given. Present the first visual fly-throughs of living tumor (rat osteogenic sarcoma tumor spheroids) using direct optical imaging. Tumor spheroids were grown to diameters of nearly half a millimeter using a clonal derivative of a transplantable rat osteosarcoma (UMR-106; American Type Culture Collection # CRL-1661, Rockville, MD). By selecting the input intensity on the tumor, the imaging system, and the relative intensity between the signal and reference beams, we successfully obtained the fly-throughs of rat tumor spheroids (a characteristic data-volume is shown. Larger spheroids have increasingly complex inner structure including necrosis, calcification, and fluid-filled voids. These features produce highly structured coherent images.