DocumentCode
2272741
Title
Anterior cruciate ligament fibroblast response to changes in polymer nanofiber scaffold composition
Author
Subramony, S.D. ; Tracey, M.S. ; Erisken, C. ; Elasmai, M.Y. ; Lu, H.H.
Author_Institution
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA
fYear
2010
fDate
26-28 March 2010
Firstpage
1
Lastpage
2
Abstract
In this article, significant differences in cell growth and gene expression have been detected on PLGA and PCL scaffolds. Specifically, cell proliferation on the PCL based scaffolds has been found to be significantly greater than on the PLGA based scaffolds after four weeks in vitro. Results also suggest that differences in scaffold mechanical properties regulate the expression of key extracellular matrix components.
Keywords
biomechanics; biomedical materials; injuries; nanobiotechnology; nanofibres; polymers; tissue engineering; PCL scaffolds; PLGA scaffolds; anterior cruciate ligament fibroblast; cell growth; cell proliferation; gene expression; poly-¿-caprolactone scaffolds; polylactide-co-glycolide scaffolds; polymer nanofiber scaffold composition; Cells (biology); DNA; Fibroblasts; Gene expression; Lakes; Ligaments; Mechanical factors; Morphology; Polymers; Visualization;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location
New York, NY
Print_ISBN
978-1-4244-6879-9
Type
conf
DOI
10.1109/NEBC.2010.5458149
Filename
5458149
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