Title :
Anterior cruciate ligament fibroblast response to changes in polymer nanofiber scaffold composition
Author :
Subramony, S.D. ; Tracey, M.S. ; Erisken, C. ; Elasmai, M.Y. ; Lu, H.H.
Author_Institution :
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA
Abstract :
In this article, significant differences in cell growth and gene expression have been detected on PLGA and PCL scaffolds. Specifically, cell proliferation on the PCL based scaffolds has been found to be significantly greater than on the PLGA based scaffolds after four weeks in vitro. Results also suggest that differences in scaffold mechanical properties regulate the expression of key extracellular matrix components.
Keywords :
biomechanics; biomedical materials; injuries; nanobiotechnology; nanofibres; polymers; tissue engineering; PCL scaffolds; PLGA scaffolds; anterior cruciate ligament fibroblast; cell growth; cell proliferation; gene expression; poly-¿-caprolactone scaffolds; polylactide-co-glycolide scaffolds; polymer nanofiber scaffold composition; Cells (biology); DNA; Fibroblasts; Gene expression; Lakes; Ligaments; Mechanical factors; Morphology; Polymers; Visualization;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458149
