Title :
VACNF arrays for recording dopamine concentrations in the brain
Author :
Lamprecht, M.R. ; McKnight, T.E. ; Ericson, M.N. ; Morrison, B., III
Abstract :
Vertically aligned carbon nanofiber (VACNF) electrode arrays were tested for their potential application in recording neuro-chemical activity. Because the electrodes are carbon-based, these arrays have potential advantages over metal electrodes and could enable a variety of future applications as precise, informative, and biocompatible neural interfaces. Dopamine (DA) concentrations were recorded in the physiological nanomolar range. Future work aims to use these devices for recording dopamine uptake kinetics in acute brain slice cultures.
Keywords :
biochemistry; biomedical electrodes; biomedical materials; biomedical measurement; biosensors; brain; carbon fibres; chemical sensors; chemical variables measurement; molecular biophysics; nanobiotechnology; nanostructured materials; neurophysiology; proteins; biocompatible neural interfaces; brain; dopamine concentrations; dopamine uptake kinetics; electrode arrays; neuro-chemical activity; vertically aligned carbon nanofiber; Biological tissues; Brain; Data analysis; Electrodes; Kinetic theory; Nanobioscience; Neural network hardware; Neurotransmitters; Sensor arrays; Testing; Neural network hardware; biological tissues; electrochemical analysis;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458154
