Title :
Imaging of fluorescence, absorption, and scattering properties in diffuse media using pump and emission wavelength measurements
Author :
Milstein, A.B. ; Oh, S. ; Webb, K.J. ; Bouman, C.A. ; Millane, R.P.
Author_Institution :
Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA
Abstract :
Summary from only given. Optical diffusion imaging, where the scattering and absorption properties of tissue are reconstructed from noninvasive measurements, offers potential advantages of safety and diagnostic specificity over other imaging modalities. In addition, fluorescent contrast agents may provide enhanced chemical specificity, with greater potential to distinguish between diseased and healthy tissue. Imaging simulations of fluorescence lifetime and yield have assumed known scattering and partially known absorption properties. In this work we demonstrate a Bayesian reconstruction in which absorption and scattering parameters at the excitation and emission wavelengths are imaged, in addition to the fluorescent yield and lifetime.
Keywords :
Bayes methods; biomedical optical imaging; fluorescence; light absorption; light scattering; Bayesian reconstruction; absorption parameters; diffuse media; diseased tissue; emission wavelength measurement; enhanced chemical specificity; fluorescent lifetime; fluorescent yield; healthy tissue; pump wavelength measurement; scattering parameters; Absorption; Fluorescence; Image reconstruction; Noninvasive treatment; Optical imaging; Optical pumping; Optical scattering; Safety; Stimulated emission; Wavelength measurement;
Conference_Titel :
Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the
Conference_Location :
Long Beach, CA, USA
Print_ISBN :
1-55752-706-7
DOI :
10.1109/CLEO.2002.1034321
