Title :
Computer generation of fibrillation in a 3-dimensional model of heart
Author :
Thakor, Nitish V. ; Eisenman, L.N.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Sch. of Med., Baltimore, MD, USA
Abstract :
A three-dimensional (3-D) model of electrical propagation in the heart is presented. The model is constructed by discretizing a real dog heart into 1473 cubic elements with 3-mm sides. Each cellular element can be in one of five states: excitable, three relatively refractory, and unexcitable. In the excitable or relatively refractory states an element can propagate, with varying velocities, the electrical excitation in 3 D to its neighbors. Pacing this model results in normal action potentials and propagation, while extra simulation results in fibrillation. The simulations show that fibrillation results from rapid re-excitation of cellular elements and dispersion refractory states in the cell population
Keywords :
bioelectric phenomena; biology computing; cardiology; digital simulation; physiological models; 3D model; action potentials; cardiac electrical propagation; cell population; cellular elements; computer generated fibrillation; dispersion refractory states; heart; pacing; Animals; Anisotropic magnetoresistance; Biomedical computing; Biomedical engineering; Chaos; Computational modeling; Electrodes; Fibrillation; Heart rate variability; Rhythm;
Conference_Titel :
Computers in Cardiology, 1988. Proceedings.
Conference_Location :
Washington, DC
Print_ISBN :
0-8186-1949-X
DOI :
10.1109/CIC.1988.72642
