Title :
Control the movement of a single dsDNA by DEP
Author :
Chang, Chia-Jung ; Wang, Pen-Cheng ; Tseng, Fan-Gang
Author_Institution :
Eng. & Syst. Sci. Dept., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
In this paper we demonstrate the adoption of both electrophoresis (EP) and dielectrophoretic (DEP) forces to control the movement of a single DNA and stretch this DNA as a stretched bridge across two Al metal electrodes at specific positions. The moving speed of the single DNA molecule can also be manipulated from 0.615 to 2.285μm/s inside a nano-pore region by DEP controlling the opening size of the virtual nanopore. The control of stretched DNA linear structure and moving speed will be the first step toward single DNA base pair detection in rapid nano pore DNA sequencing technology in the future.
Keywords :
DNA; biological techniques; electrophoresis; molecular biophysics; nanobiotechnology; DEP; DNA sequencing; base pair detection; dielectrophoretic forces; dsDNA; electrophoresis; movement control; virtual nanopore; DEP; DNA; sequencing; stretched;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on
Conference_Location :
Seoul
Print_ISBN :
978-1-4244-7033-4
Electronic_ISBN :
1944-9399
DOI :
10.1109/NANO.2010.5697863