DocumentCode :
2289518
Title :
Synthesis and characterization of ²-cyclodextrin-grafted chitosan derivatives on its mucoadhesion and antibacterial activities
Author :
Nuchuchua, Onanong ; Sajomsang, Warayuth ; Gonil, Pattarapond ; Pimphd, N. ; Chaleawlert-Umpon, Saowaluk ; Sramala, Issara ; Saesoo, Somsak ; Soottitantawat, A. ; Ruktanonchai, Uracha Rungsardthong
Author_Institution :
Nat. Center of Nanotechnol., NSTDA, Thailand
fYear :
2010
fDate :
17-20 Aug. 2010
Firstpage :
1056
Lastpage :
1059
Abstract :
The aims of this study were to synthesize and determine the biological activities of two types of water-soluble βCD-grafted chitosan derivatives; βCD-grafted chitosan with spacer (QCDCA22-g-CS) and βCD-grafted chitosan without spacer (QCD23-g-CS) as a novel biomaterial for mucosal delivery. Difference in their chemical structure were defined by 1H-NMR According to mucin particle method, QCD23-g-CS showed stronger mucoadhesion towards mucin. Although both QCDCA22-g-CS and QCD23-g-CS demonstrated high antibacterial activity towards Candida albicans at 24 hours, QCD23-g-CS demonstrated much higher activity than QCDCA22-g-CS.
Keywords :
adhesion; antibacterial activity; biochemistry; biological NMR; biomechanics; biomedical materials; cellular biophysics; chemical structure; microorganisms; polymers; proton magnetic resonance; β-cyclodextrin-grafted chitosan derivatives; 1H-NMR; Candida albicans; antibacterial activity; biological activities; biomaterial; chemical structure; mucin particle method; mucoadhesion; mucosal delivery; water-solubility;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on
Conference_Location :
Seoul
ISSN :
1944-9399
Print_ISBN :
978-1-4244-7033-4
Electronic_ISBN :
1944-9399
Type :
conf
DOI :
10.1109/NANO.2010.5698027
Filename :
5698027
Link To Document :
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