An internally amplified signal SOI nano-bridge biosensor for electrical detection of DNA hybridization

Author

Parizi, K.B. ; Melosh, N. ; Nishi, Y.

Author_Institution

Electr. Eng. Dept., Stanford Univ., Stanford, CA, USA

fYear

2009

fDate

5-8 Oct. 2009

Firstpage

1

Lastpage

2

Abstract

Despite all technical improvements in semiconductor industry, technology development in biomedicine still requires a lot of improvement to satisfy the current need. Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and disease discovery due to real time, low cost, ease of miniaturization and label-free operation. This paper outlines how the modulation of impedance in a novel silicon nano-bridge (nanowire) biosensor can be used in characterizing biochemical species such as an antibodies/antigens or for detection of a particular DNA sequence hybridization.

Keywords

DNA; biochemistry; biosensors; molecular biophysics; nanobiotechnology; silicon-on-insulator; DNA hybridization; antibodies; antigens; biochemical species; disease discovery; electrical detection; impedance biosensors; internally amplified signal SOI biosensor; point-of-care; silicon nanobridge biosensor; Biological system modeling; Biosensors; DNA; Etching; Impedance; Nanobioscience; Nanoscale devices; Rough surfaces; Sensor phenomena and characterization; Surface roughness;

fLanguage

English

Publisher

ieee

Conference_Titel

SOI Conference, 2009 IEEE International

Conference_Location

Foster City, CA

ISSN

1078-621X

Print_ISBN

978-1-4244-4256-0

Electronic_ISBN

1078-621X

Type

conf

DOI

10.1109/SOI.2009.5318775

Filename

5318775