Title :
Silicon photonic crystal microcavity biosensors for label free highly sensitive and specific lung cancer detection
Author :
Lai, Wei-Cheng ; Chakravarty, Swapnajit ; Zou, Yi ; Drabkin, Harry A. ; Gemmill, Robert M. ; Simon, George R. ; Chin, Steve H. ; Chen, Ray T.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Texas Austin, Austin, TX, USA
Abstract :
We experimentally detect lung cancer cell lysates with high sensitivity down to 2 cells per microliter with silicon based photonic crystal microcavity sensors. Label free specificity is achieved via sandwiched assays and simultaneous multiplexed detection.
Keywords :
bioMEMS; biosensors; cancer; cellular biophysics; elemental semiconductors; enzymes; lung; microcavities; microsensors; molecular biophysics; photonic crystals; sensitivity; silicon; silicon-on-insulator; Si; label free highly sensitive lung cancer detection; label free highly specific lung cancer Detection; lung cancer cell lysates; sandwiched assays; silicon photonic crystal microcavity biosensors; simultaneous multiplexed detection; Biosensors; Cancer; Lungs; Microcavities; Photonic crystals; Sensitivity; Silicon; Cancer Cell; Multimode Interference (MMI); Photonic Crystal Microcavity; Sandwiched Assay;
Conference_Titel :
Photonics Conference (IPC), 2012 IEEE
Conference_Location :
Burlingame, CA
Print_ISBN :
978-1-4577-0731-5
DOI :
10.1109/IPCon.2012.6358683
