Studying mammalian development with optical coherence tomography

Author

Larina, Irina V. ; Dickinson, Mary E. ; Larin, Kirill V.

Author_Institution

Dept. Mol. Physiol. & Biophys., Baylor Coll. of Med., Houston, TX, USA

fYear

2011

fDate

8-10 June 2011

Firstpage

1

Lastpage

3

Abstract

The mouse provides an excellent model for studying mammalian development and disease because of the resemblance to humans, potential for genetic manipulation, and rapid generation time. However, mammalian embryos develop in utero, which limits the ability to observe development with high-resolution. In this study, we adopted Swept Source Optical Coherence Tomography (SS-OCT) for live visualization of mouse embryos during different stages of the development. We demonstrate capability of OCT as a novel methodology for live imaging of mouse embryos both in culture and through the uterine wall.

Keywords

biomedical optical imaging; cellular biophysics; genetics; gynaecology; optical tomography; cell culture; disease; genetic manipulation; mammalian development; mammalian embryos; mouse; mouse embryos; optical coherence tomography; rapid generation time; swept source optical coherence tomography; uterine wall; Biological systems; Biomedical optical imaging; Heating; Image resolution; Optical imaging; Surgery; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

BioPhotonics, 2011 International Workshop on

Conference_Location

Parma

Print_ISBN

978-1-4244-9836-9

Electronic_ISBN

978-1-4244-9835-2

Type

conf

DOI

10.1109/IWBP.2011.5954819

Filename

5954819