Title :
A novel method to monitor the storage stability of pharmaceutical tablets using terahertz time-domain spectroscopy
Author :
Nativivat, V. ; Zhao, L. ; Gladden, L.F. ; Zeitler, J.A.
Author_Institution :
Dept. of Chem. Eng. & Biotechnol., Univ. of Cambridge, Cambridge, UK
Abstract :
Due to its inherent sensitivity to both subtle changes in crystal structure and the hydrogen bonding network of organic molecular crystals and moisture, terahertz time-domain spectroscopy (THz-TDS) is a very promising technique to study physico-chemical changes during stability testing of pharmaceutical dosage forms. Using a variable temperature and humidity chamber the effects of moisture and temperature can be studied in the tablet formulation in situ by terahertz spectroscopy.
Keywords :
crystal structure; humidity; hydrogen bonds; moisture; organic compounds; pharmaceuticals; terahertz wave spectra; A temperature effects; crystal structure; humidity chamber; hydrogen bonds; moisture effects; pharmaceutical tablets; physico-chemical changes; storage stability; terahertz time-domain spectroscopy; Bonding; Crystals; Hydrogen; Moisture; Monitoring; Pharmaceuticals; Spectroscopy; Stability; Testing; Time domain analysis;
Conference_Titel :
Infrared, Millimeter, and Terahertz Waves, 2009. IRMMW-THz 2009. 34th International Conference on
Conference_Location :
Busan
Print_ISBN :
978-1-4244-5416-7
Electronic_ISBN :
978-1-4244-5417-4
DOI :
10.1109/ICIMW.2009.5324640
