A novel method to monitor the storage stability of pharmaceutical tablets using terahertz time-domain spectroscopy

Author

Nativivat, V. ; Zhao, L. ; Gladden, L.F. ; Zeitler, J.A.

Author_Institution

Dept. of Chem. Eng. & Biotechnol., Univ. of Cambridge, Cambridge, UK

fYear

2009

fDate

21-25 Sept. 2009

Firstpage

1

Lastpage

2

Abstract

Due to its inherent sensitivity to both subtle changes in crystal structure and the hydrogen bonding network of organic molecular crystals and moisture, terahertz time-domain spectroscopy (THz-TDS) is a very promising technique to study physico-chemical changes during stability testing of pharmaceutical dosage forms. Using a variable temperature and humidity chamber the effects of moisture and temperature can be studied in the tablet formulation in situ by terahertz spectroscopy.

Keywords

crystal structure; humidity; hydrogen bonds; moisture; organic compounds; pharmaceuticals; terahertz wave spectra; A temperature effects; crystal structure; humidity chamber; hydrogen bonds; moisture effects; pharmaceutical tablets; physico-chemical changes; storage stability; terahertz time-domain spectroscopy; Bonding; Crystals; Hydrogen; Moisture; Monitoring; Pharmaceuticals; Spectroscopy; Stability; Testing; Time domain analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Infrared, Millimeter, and Terahertz Waves, 2009. IRMMW-THz 2009. 34th International Conference on

Conference_Location

Busan

Print_ISBN

978-1-4244-5416-7

Electronic_ISBN

978-1-4244-5417-4

Type

conf

DOI

10.1109/ICIMW.2009.5324640

Filename

5324640